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Product Name
humanin antibody
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Description
humanin Rabbit Polyclonal antibody. Positive FC detected in SH-SY5Y cells. Positive IHC detected in human colon tissue, human heart tissue, human small intestine tissue.
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Tested applications
ELISA, IHC, FC
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Species reactivity
Human; other species not tested.
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Alternative names
humanin antibody; l rRNA antibody; MTRNR2 antibody; RNR2 antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of Peptide (Accession Number: NC_012920). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
IHC: 1:20-1:200
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Validations
1X10^6 SH-SY5Y cells were stained with 0.2ug humanin antibody (Catalog No:111724, red) and control antibody (blue). Fixed with 90% MeOH blocked with 3% BSA (30 min). Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L) with dilution 1:1000.
Immunohistochemistry of paraffin-embedded human colon tissue slide using Catalog No:111724(humanin Antibody) at dilution of 1:50 (under 10x lens)
Immunohistochemistry of paraffin-embedded human colon tissue slide using Catalog No:111724(humanin Antibody) at dilution of 1:50 (under 40x lens)
Immunohistochemistry of paraffin-embedded human heart tissue slide using Catalog No:111724(humanin Antibody) at dilution of 1:50 (under 10x lens)
Immunohistochemistry of paraffin-embedded human heart tissue slide using Catalog No:111724(humanin Antibody) at dilution of 1:50 (under 40x lens)
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Background
Humanin, also named as MT-RNR2, is a mitochondrial peptide. It plays a role as a neuroprotective factor. It protects against death induced by multiple different familial Alzheimer disease genes and beta amyloid proteins in Alzheimer disease. Humanin reduces the aggregation and fibrillary formation by suppressing the effect of APP on mononuclear phagocytes and acts by competitively inhibiting the access of FPRL1 to APP.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"