Human VPS4A Recombinant protein (GST tag)

Human VPS4A Recombinant protein (GST tag)

• DataSheet
• Material Safety Data Sheets (MSDS)

Involved in late steps of the endosomal multivesicular bodies (MVB) pathway. Recognizes membrane-associated ESCRT-III assemblies and catalyzes their disassembly, possibly in combination with membrane fission. Redistributes the ESCRT-III components to the cytoplasm for further rounds of MVB sorting. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. In conjunction with the ESCRT machinery also appears to function in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and enveloped virus budding (HIV-1 and other lentiviruses). Involved in cytokinesis: retained at the midbody by ZFYVE19/ANCHR and CHMP4C until abscission checkpoint signaling is terminated at late cytokinesis. It is then released following dephosphorylation of CHMP4C, leading to abscission (PubMed:24814515). {PubMed:11563910, PubMed:11595185, PubMed:15075231, PubMed:24814515}.

Vacuolar protein sorting-associated protein 4A

VPS4

Q9UN37

VPS4A; VPS4

E. coli

A DNA sequence encoding the human VPS4A (NP_037377.1) 86-437 aa was fused with the N-terminal GST tag

Human

Not tested.