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  • Recombinant Human UHRF1 protein

Recombinant Human UHRF1 protein

Cat.#: 528813

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Product Information

  • Product Name
    Recombinant Human UHRF1 protein
  • Documents
  • Description
    Multidomain protein that acts as a key epigenetic regulator by bridging DNA methylation and chromatin modification. Specifically recognizes and binds hemimethylated DNA at replication forks via its YDG domain and recruits DNMT1 methyltransferase to ensure faithful propagation of the DNA methylation patterns through DNA replication. In addition to its role in maintenance of DNA methylation, also plays a key role in chromatin modification: through its tudor-like regions and PHD-type zinc fingers, specifically recognizes and binds histone H3 trimethylated at 'Lys-9' (H3K9me3) and unmethylated at 'Arg-2' (H3R2me0), respectively, and recruits chromatin proteins. Enriched in pericentric heterochromatin where it recruits different chromatin modifiers required for this chromatin replication. Also localizes to euchromatic regions where it negatively regulates transcription possibly by impacting DNA methylation and histone modifications. Has E3 ubiquitin-protein ligase activity by mediating the ubiquitination of target proteins such as histone H3 and PML. It is still unclear how E3 ubiquitin-protein ligase activity is related to its role in chromatin in vivo. May be involved in DNA repair.
  • Protein short names
    Np95; HuNp95; hNp95; ICBP90; hUHRF1
  • Uniprot ID
    Q96T88
  • Gene Name
    E3 ubiquitin-protein ligase UHRF1
  • Source/Expression Host
    E.coli
  • Expression Plasmid/cDNA
    C-terminal 6His tag was fused to 1-793 aa encoded by NM_001048201
  • Protein Species
    Human
  • Molecular weight
    91 kDa including tags
  • Purity
    90%, by SDS-PAGE with Coomassie Brilliant Blue staining.
  • Activity
    Not tested
  • Validations

    Human E3 ubiquitin-protein ligase UHRF1

    Human E3 ubiquitin-protein ligase UHRF1

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"