Human TRP1 / TYRP1 (His Tag) recombinant protein
Tyrosinase-related protein 1, also known as TYRP1 or TRP1, is a melanosomal enzyme that belongs to the tyrosinase family and plays an important role in the melanin biosynthetic pathway. Mutations in this enzyme are the cause of rufous oculocutaneous albinism and oculocutaneous albinism type III. TYRP1 / TRP1 is involved in the oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6-quinone-2-carboxylic acid. This enzyme may regulate or influence the type of melanin synthesized. The expression of Tyrosinase-related protein 1 (TYRP1) is regulated by the microphthalmia-associated transcription factor (MITF). There is mounting evidence demonstrating that in addition to its role in eumelanin synthesis, TYRP1 is involved in maintaining stability of tyrosinase proliferation and melanocyte cell death.
5,6-dihydroxyindole-2-carboxylic acid oxidase
Protein short names
B; TYRP; TRP; OCA3; B-PROTEIN; TRP-1; TRP1; CAS2; CATB; ISA; GP75; RP11-3L8.1; BROWN
TYRP1; CAS2; TYRP; TYRRP
A DNA sequence encoding the human TYRP1 (P17643) extracellular domain (Met 1- Arg 471) was fused with a polyhistidine tag at the C-terminus.
The secreted recombinant human TYRP1 comprises 458 amino acids and has a predicted molecular mass of 52.2 kDa. The apparent molecular mass of rh TYRP1 is approximately 66 kDa in SDS-PAGE under reducing conditions due to glycosylation.
> 95 % as determined by SDS-PAGE
Human TRP1 / TYRP1 Protein (His Tag) SDS-PAGE
Related Products / Services
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"