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Product Name
Anti-TRP1 / TYRP1 antibody
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Description
Rabbit polyclonal to TRP1 / TYRP1
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Tested applications
ELISA, IHC-P
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Species reactivity
Human TRP1 / TYRP1
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Alternative names
CAS2 antibody; b-PROTEIN antibody; CAS2 antibody; CATB antibody; GP75 antibody; RP11-3L8.1 antibody; TRP antibody; TYRP antibody; isa antibody; Oca3 antibody; TRP1 antibody; Tyrp antibody; TRP-1 antibody; brown antibody; TRP antibody; CATB antibody; GP75 antibody; OCA3 antibody; TRP1 antibody; TYRP antibody; b-PROTEIN antibody; B antibody
- Immunogen
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Isotype
Rabbit IgG
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Preparation
Produced in rabbits immunized with purified, recombinant Human TRP1 / TYRP1 (rh TRP1 / TYRP1; P17643; Met1-Arg471). TRP1 / TYRP1 specific IgG was purified by Human TRP1 / TYRP1 affinity chromatography.
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Clonality
Polyclonal
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Formulation
0.2 μm filtered solution in PBS
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Storage instructions
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles. -
Applications
ELISA:0.1-0.2 μg/mL
This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Human TRP1 / TYRP1. The detection limit for Human TRP1 / TYRP1 is < 0.039 ng/well.
IHC-P: 0.1-2 μg/ml
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Validations
TRP1 / TYRP1 Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
TRP1 / TYRP1 Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
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Background
Tyrosinase-related protein 1, also known as TYRP1 or TRP1, is a melanosomal enzyme that belongs to the tyrosinase family and plays an important role in the melanin biosynthetic pathway. Mutations in this enzyme are the cause of rufous oculocutaneous albinism and oculocutaneous albinism type III. TYRP1 / TRP1 is involved in the oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6-quinone-2-carboxylic acid. This enzyme may regulate or influence the type of melanin synthesized. The expression of Tyrosinase-related protein 1 (TYRP1) is regulated by the microphthalmia-associated transcription factor (MITF). There is mounting evidence demonstrating that in addition to its role in eumelanin synthesis, TYRP1 is involved in maintaining stability of tyrosinase proliferation and melanocyte cell death.
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References
- Sarangarajan R, et al. (2001) Tyrp1 and oculocutaneous albinism type 3. Pigment Cell Res. 14(6): 437-44.
- Box NF, et al. (1998) Complete sequence and polymorphism study of the human TYRP1 gene encoding tyrosinase-related protein 1. Genome. 9 (1): 50-3.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"