Human TrkA/NTRK1 (aa 285-413, His Tag) recombinant protein

Cat.#: 503757

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Product Information

  • Product Name
    Human TrkA/NTRK1 (aa 285-413, His Tag) recombinant protein
  • Documents
  • Description
    TRKA is a member of the neurotrophic tyrosine kinase receptor (NTKR) family. It is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Isoform TrkA-III promotes angiogenesis and has oncogenic activity when overexpressed. Isoform TrkA-I is found in most non-neuronal tissues. Isoform TrkA-II is primarily expressed in neuronal cells. TrkA-III is specifically expressed by pluripotent neural stem and neural crest progenitors. The presence of NTRK1 leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in TRKA gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer. It was originally identified as an oncogene as it is commonly mutated in cancers, particularly colon and thyroid carcinomas. TRKA is required for high-affinity binding to nerve growth factor (NGF), neurotrophin-3 and neurotrophin-4/5 but not brain-derived neurotrophic factor (BDNF). Known substrates for the Trk receptors are SHC1, PI 3-kinase, and PLC-gamma-1. NTRK1 has a crucial role in the development and function of the nociceptive reception system as well as establishment of thermal regulation via sweating. It also activates ERK1 by either SHC1- or PLC-gamma-1-dependent signaling pathway. Defects in NTRK1 are a cause of congenital insensitivity to pain with anhidrosis and thyroid papillary carcinoma.
  • Protein name
    High affinity nerve growth factor receptor
  • Protein short names
    TRK-A; TRKA; C80751; NTRK1; P140-TRKA; TKR; MTC; DKFZP781I14186; TRK; TRK1
  • Uniprot ID
    P04629
  • Gene Name
    NTRK1; MTC; TRK; TRKA
  • Source/Expression Host
    E. coli
  • Expression Plasmid/cDNA
    A DNA sequence encoding the amino acid sequence (Pro 285-Glu 413) of human NTRK1 (NP_002520.2), corresponding to the Ig-like C2-type 2 domain, was expressed and purified, with a N-terminal polyhistidine tag.
  • Protein Species
    Human
  • Molecular weight
    The recombinant human NTRK1 Ig-like C2-type 2 domain (aa 285-413) consists of 136 amino acids and has a predicted molecular mass of 15.1 kDa. It migrates as an approximately 16 kDa band in SDS-PAGE under reducing conditions.
  • Purity
    > 97 % as determined by SDS-PAGE
  • Validations

    Human TrkA / NTRK1 Protein (aa 285-413, His Tag) SDS-PAGE

    Human TrkA / NTRK1 Protein (aa 285-413, His Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"