Human Transferrin Receptor/TFRC/CD71 (His Tag) recombinant protein

Human Transferrin Receptor/TFRC/CD71 (His Tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

Mouse transferrin receptor protein 1, also known as transferrin receptor, Trfr, p90, CD71 and TFRC, is a single-pass type II membrane protein which belongs to the peptidase M28 family and M28B subfamily. TFRC / CD71 is a membrane-bound protein expressed in larger amounts in proliferating. The specific expression of TFRC can represent a diagnostic tool or a therapeutic target in solid tumours expressing this antigen. Transferrin receptor is necessary for development of erythrocytes and the nervous system. TFRC / CD71 is regulated by cellular iron levels through binding of the iron regulatory proteins, IRP1 and IRP2, to iron-responsive elements in the 3'-UTR. Up-regulated upon mitogenic stimulation. TFRC / CD71 represents a marker of malignant transformation in the pancreas that could be applied as potential diagnostic and therapeutic target.

TR; TFRC; AI195355; T9; 2610028K12RIK; TFR1; TRFR; MTVR1; MTVR-1; E430033M20RIK; AI426448; TFR; TRANSFERRIN RECEPTOR; P90; AU015758; CD71

P02786

Human Cells

A DNA sequence encoding the extracellular domain of human TFRC (NP_003225.2) (Cys 89-Phe 760) was expressed with a polyhistidine tag at the N-terminus.

Human

The recombinant human TFRC comprises 689 amino acids and has a predicted molecular mass of 77.4 kDa.

> 85 % as determined by SDS-PAGE

Measured by its binding ability in a functional ELISA. Immobilized human CD71 at 10 μg/ml (100 μl/well) can bind human Transferrin. The EC₅₀ of human Transferrin is 5.6 ng/mL.