Cynomolgus Transferrin Receptor/TFRC/CD71 (His Tag) recombinant protein

Cynomolgus Transferrin Receptor/TFRC/CD71 (His Tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

Mouse transferrin receptor protein 1, also known as transferrin receptor, Trfr, p90, CD71 and TFRC, is a single-pass type II membrane protein which belongs to the peptidase M28 family and M28B subfamily. TFRC / CD71 is a membrane-bound protein expressed in larger amounts in proliferating. The specific expression of TFRC can represent a diagnostic tool or a therapeutic target in solid tumours expressing this antigen. Transferrin receptor is necessary for development of erythrocytes and the nervous system. TFRC / CD71 is regulated by cellular iron levels through binding of the iron regulatory proteins, IRP1 and IRP2, to iron-responsive elements in the 3'-UTR. Up-regulated upon mitogenic stimulation. TFRC / CD71 represents a marker of malignant transformation in the pancreas that could be applied as potential diagnostic and therapeutic target.

Transferrin receptor 1

MTVR1; TRFR; TR; TFRC; TFR1; 2610028K12RIK; T9; AI195355; TRANSFERRIN RECEPTOR; TFR; CD71; P90; AU015758; AI426448; E430033M20RIK; MTVR-1

F6UX47

TFRC; Tfrc

Human Cells

A DNA sequence encoding the cynomolgus TFRC (NP_001244232.1) (Cys89-Phe760) was expressed with a polyhistidine tag at the N-terminus.

Cynomolgus

The recombinant cynomolgus TFRC comprises 692 amino acids and has a calculated molecular mass of 77.6 KDa. The apparent molecular mass of it is approximately 65-85 KDa in SDS-PAGE under reducing conditions.

> 95 % as determined by SDS-PAGE

Measured by its ability to neutralize transferrin-mediated effect on proliferation of MCF-7 cells.
The ED₅₀ for this effect is typically 2-10 μg/mL.