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  • Cynomolgus Transferrin Receptor/TFRC/CD71 (His Tag) recombinant protein

Cynomolgus Transferrin Receptor/TFRC/CD71 (His Tag) recombinant protein

Cat.#: 504204

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Product Information

  • Product Name
    Cynomolgus Transferrin Receptor/TFRC/CD71 (His Tag) recombinant protein
  • Documents
  • Description
    Mouse transferrin receptor protein 1, also known as transferrin receptor, Trfr, p90, CD71 and TFRC, is a single-pass type II membrane protein which belongs to the peptidase M28 family and M28B subfamily. TFRC / CD71 is a membrane-bound protein expressed in larger amounts in proliferating. The specific expression of TFRC can represent a diagnostic tool or a therapeutic target in solid tumours expressing this antigen. Transferrin receptor is necessary for development of erythrocytes and the nervous system. TFRC / CD71 is regulated by cellular iron levels through binding of the iron regulatory proteins, IRP1 and IRP2, to iron-responsive elements in the 3'-UTR. Up-regulated upon mitogenic stimulation. TFRC / CD71 represents a marker of malignant transformation in the pancreas that could be applied as potential diagnostic and therapeutic target.
  • Protein name
    Transferrin receptor 1
  • Protein short names
    MTVR1; TRFR; TR; TFRC; TFR1; 2610028K12RIK; T9; AI195355; TRANSFERRIN RECEPTOR; TFR; CD71; P90; AU015758; AI426448; E430033M20RIK; MTVR-1
  • Uniprot ID
    F6UX47
  • Gene Name
    TFRC; Tfrc
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the cynomolgus TFRC (NP_001244232.1) (Cys89-Phe760) was expressed with a polyhistidine tag at the N-terminus.
  • Protein Species
    Cynomolgus
  • Molecular weight
    The recombinant cynomolgus TFRC comprises 692 amino acids and has a calculated molecular mass of 77.6 KDa. The apparent molecular mass of it is approximately 65-85 KDa in SDS-PAGE under reducing conditions.
  • Purity
    > 95 % as determined by SDS-PAGE
  • Activity
    Measured by its ability to neutralize transferrin-mediated effect on proliferation of MCF-7 cells.
    The ED50 for this effect is typically 2-10 μg/mL.
  • Validations

    Cynomolgus Transferrin Receptor / TFRC / CD71 Protein (His Tag) SDS-PAGE

    Cynomolgus Transferrin Receptor / TFRC / CD71 Protein (His Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"