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Product Name
Mouse Transferrin Receptor/TFRC/CD71 (His Tag) recombinant protein
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Description
Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity).
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Protein name
Transferrin receptor protein 1
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Protein short names
TFR1; 2610028K12RIK; T9; AI195355; TFRC; TR; TRFR; MTVR1; AI426448; E430033M20RIK; MTVR-1; CD71; P90; AU015758; TRANSFERRIN RECEPTOR; TFR
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Uniprot ID
Q62351
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Gene Name
Tfrc; Trfr
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the extracellular domain of mouse TFRC (Q62351) (Cys 89-Phe 763) was fused with a polyhistidine tag at the N-terminus.
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Protein Species
Mouse
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Molecular weight
The recombinant mouse TFRC comprises 694 amino acids and predicts a molecular mass of 78.3 kDa. The apparent molecular mass of mouse TFRC is approximately 80 kDa in SDS-PAGE under reducing conditions.
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Purity
> 92 % as determined by SDS-PAGE
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Validations
Mouse Transferrin Receptor / TFRC / CD71 Protein (His Tag) SDS-PAGE
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