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Product Name
Human TPM1/C15orf13/TMSA (His tag) recombinant protein
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Description
Tropomyosin α-1 Chain (TPM1) is a member of the Tropomyosin family of highly conserved and widely distributed Actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. TPM1 binds to Actin filaments in both muscle and non-muscle cells. It is one type of α-helical chain that forms the predominant Tropomyosin of striated muscle. TPM1 plays a central role in association with the Troponin complex and the Calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with Caldesmon. In non-muscle cells, it is implicated in stabilizing the cytoskeleton Actin filaments. Defects in TPM1 are associated with type 3 Familial Hypertrophic Cardiomyopathy.
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Protein name
tropomyosin 1 (alpha)(TPM1)
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Protein short names
C15orf13; TMSA
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Uniprot ID
P09493
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Source/Expression Host
E.coli
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Expression Plasmid/cDNA
A DNA sequence encoding the Human TPM1/C15orf13/TMSA Met1-Met284 is expressed with a 6His tag at the N-terminus.
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Protein Species
Human
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Purity
>95% as determined by SDS-PAGE.
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Validations
Human TPM1/C15orf13/TMSA (His tag) recombinant protein
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