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Product Name
Human TNFRSF21/DR6/UNQ437/PRO868 (Fc tag) recombinant protein
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Description
Tumor Necrosis Factor Receptor Superfamily Member 21 (TNFRSF21) is a type I transmembrane receptor that includes four extracellular cysteine-rich motifs and a cytoplasmic death domain. DR6 is highly expressed in heart, brain, placenta, pancreas, lymph node, thymus and prostate. DR6 may activate NF-kappa-B and JNK to promote apoptosis and T-cell differentiation. In addition, DR6 binds with N-APP, which is released by the deprivation of Trophic-factor. It triggers caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6). DR6 is also expressed on the tumor cell lines and can be induced by TNF-α.
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Protein name
TNF receptor superfamily member 21(TNFRSF21)
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Protein short names
DR6; UNQ437; PRO868
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Uniprot ID
O75509
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the Human TNFRSF21/DR6/UNQ437/PRO868 Gln42-Leu350 is expressed with a Fc tag at the C-terminus.
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Protein Species
Human
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Purity
>95% as determined by SDS-PAGE.
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Validations
Human TNFRSF21/DR6/UNQ437/PRO868 (Fc tag) recombinant protein
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