Cynomolgus TNFRSF21/DR6 (His Tag) recombinant protein

Cynomolgus TNFRSF21/DR6 (His Tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

TNFRSF21 (death receptor-6, DR6) is an orphan TNF receptor superfamily member and belongs to a subgroup of receptors called death receptors. This type I transmembrane receptor possesses four extracellular cysteine-rich motifs and a cytoplasmic death domain. DR6 is an extensively posttranslationally modified transmembrane protein and that N- and O-glycosylations of amino acids in its extracellular part. DR6 interacts with the adaptor protein TRADD and mediates signal transduction through its death domain, and expression of DR6 in mammalian cells induces activation of both NF-kappaB and JNK and cell apoptosis. DR6 knockout mice have enhanced CD4+ T cell proliferation and Th2 cytokine production, suggested that DR6 serves as an important regulatory molecule in T-helper cell activation, and is involved in inflammation and immune regulation. DR6 is expressed ubiquitously with high expression in lymphoid organs, heart, brain and pancreas. Some tumor cells overexpress DR6, typically in conjunction with elevated anti-apoptosis molecules. DR6 may also be involved in tumor cell survival and immune evasion, which is subject to future investigations.

MGC31965; TNFRSF21; AA959878; TR7; BM-018; CD358; DR6; R74815

G7MPI5

Human Cells

A DNA sequence encoding the cynomolgus TNFRSF21 (XP_005552846.1) (Met1-Leu350) was expressed with a polyhistidine tag at the C-terminus.

Cynomolgus

The recombinant cynomolgus TNFRSF21 consists 320 amino acids and predicts a molecular mass of 35 kDa.

> 95 % as determined by SDS-PAGE.

Measured by its ability to bind with APP-Fc(Cat:501404) in a functional ELISA.