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Product Name
Human THOP1 (His tag) recombinant protein
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Description
Thimet Oligopeptidase (THOP1) belongs to the peptidase M3 family which includes neurolysin and mitochondrial intermediate peptidase. THOP1 is located in Cytoplasm. THOP1 is widely expressed in human tissues and can detected in different subcellular locations. THOP1 is preferential cleavage for bonds with hydrophobic residues at P1, P2 and P3' and a small residue at P1' in substrates of 5 to 15 residues. THOP1 is involved in the metabolism of neuropeptides under 20 amino acid residues and degradation of cytoplasmic peptide. In addition, THOP1 also can degrade the beta-amyloid precursor protein and generate amyloidogenic fragments.
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Protein name
thimet oligopeptidase 1(THOP1)
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Uniprot ID
P52888
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
A DNA sequence encoding the Human THOP1 Lys2-Cys689 is expressed with a 6His tag at the C-terminus.
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Protein Species
Human
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Purity
>95% as determined by SDS-PAGE.
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Validations
Human THOP1 (His tag) recombinant protein
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