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Product Name
Mouse THOP1 (His Tag) recombinant protein
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Description
Involved in the metabolism of neuropeptides under 20 amino acid residues long. Involved in cytoplasmic peptide degradation. Able to degrade the beta-amyloid precursor protein and generate amyloidogenic fragments (By similarity).
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Protein name
Thimet oligopeptidase
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Protein short names
THOP1; AI327041; MP78; MEPD_HUMAN; AI131655; EP24.15; TOP
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Uniprot ID
Q8C1A5
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Gene Name
Thop1
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Source/Expression Host
Baculovirus-Insect Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the mouse THOP1 (NP_073144.3) (Lys 2-Cys 687) was fused with a polyhistidine tag at the N-terminus.
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Protein Species
Mouse
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Molecular weight
The recombinant mouse THOP1 consists of 705 amino acids and has a calculated molecular mass of 80.1 kDa. It migrates as an approximately 75 kDa band in SDS-PAGE under reducing conditions.
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Purity
> 90 % as determined by SDS-PAGE
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Activity
Measured by its ability to cleave a fluorogenic peptide substrate, (7-methoxycoumarin-4-yl)acetyl-Pro-Leu-Gly-Pro-D-Lys(2,4-dinitrophenyl)-OH or Mca-PLGPK(Dnp)-OH.
The specific activity is > 500 pmoles/min/μg. -
Validations
Mouse THOP1 Protein (His Tag) SDS-PAGE
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