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Product Name
Human THOC7 Recombinant protein (His tag)
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Description
Required for efficient export of polyadenylated RNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. {PubMed:15833825, PubMed:15998806, PubMed:17190602, PubMed:23222130}.; The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. {PubMed:18974867}.
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Protein name
THO complex subunit 7 homolog
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Protein short names
NIF3L1BP1
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Uniprot ID
Q6I9Y2
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Gene Name
THOC7; NIF3L1BP1
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
A DNA sequence encoding the human THOC7 (NP_079351.2) 1-204 aa was fused with the polyhistidine tag
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Protein Species
Human
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Activity
Not tested.
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Validations
Recombinant human THOC7(Full length) SDS-PAGE
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