Human STIM2 Recombinant protein (GST tag)

Human STIM2 Recombinant protein (GST tag)

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Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Functions as a highly sensitive Ca(2+) sensor in the endoplasmic reticulum which activates both store-operated and store-independent Ca(2+)-influx. Regulates basal cytosolic and endoplasmic reticulum Ca(2+) concentrations. Upon mild variations of the endoplasmic reticulum Ca(2+) concentration, translocates from the endoplasmic reticulum to the plasma membrane where it probably activates the Ca(2+) release-activated Ca(2+) (CRAC) channels ORAI1, ORAI2 and ORAI3. May inhibit STIM1-mediated Ca(2+) influx. {PubMed:16005298, PubMed:16860747, PubMed:17905723, PubMed:18160041, PubMed:21217057, PubMed:22464749, PubMed:23359669}.

Stromal interaction molecule 2

KIAA1482

Q9P246

STIM2; KIAA1482

E. coli

A DNA sequence encoding the human STIM2 (NP_001162589.1) 446-595 aa was fused with the N-terminal GST tag

Human

Not tested.