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Product Name
Human STIM2 Recombinant protein (GST tag)
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Description
Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Functions as a highly sensitive Ca(2+) sensor in the endoplasmic reticulum which activates both store-operated and store-independent Ca(2+)-influx. Regulates basal cytosolic and endoplasmic reticulum Ca(2+) concentrations. Upon mild variations of the endoplasmic reticulum Ca(2+) concentration, translocates from the endoplasmic reticulum to the plasma membrane where it probably activates the Ca(2+) release-activated Ca(2+) (CRAC) channels ORAI1, ORAI2 and ORAI3. May inhibit STIM1-mediated Ca(2+) influx. {PubMed:16005298, PubMed:16860747, PubMed:17905723, PubMed:18160041, PubMed:21217057, PubMed:22464749, PubMed:23359669}.
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Protein name
Stromal interaction molecule 2
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Protein short names
KIAA1482
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Uniprot ID
Q9P246
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Gene Name
STIM2; KIAA1482
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
A DNA sequence encoding the human STIM2 (NP_001162589.1) 446-595 aa was fused with the N-terminal GST tag
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Protein Species
Human
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Activity
Not tested.
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Validations
Recombinant human STIM2 SDS-PAGE
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