Human RLIM Recombinant protein (His tag)

Human RLIM Recombinant protein (His tag)

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E3 ubiquitin-protein ligase. Acts as a negative coregulator for LIM homeodomain transcription factors by mediating the ubiquitination and subsequent degradation of LIM cofactors LDB1 and LDB2 and by mediating the recruitment the SIN3a/histone deacetylase corepressor complex. Ubiquitination and degradation of LIM cofactors LDB1 and LDB2 allows DNA-bound LIM homeodomain transcription factors to interact with other protein partners such as RLIM. Plays a role in telomere length-mediated growth suppression by mediating the ubiquitination and degradation of TERF1. By targeting ZFP42 for degradation, acts as an activator of random inactivation of X chromosome in the embryo, a stochastic process in which one X chromosome is inactivated to minimize sex-related dosage differences of X-encoded genes in somatic cells of female placental mammals. {PubMed:19164295, PubMed:19945382}.

E3 ubiquitin-protein ligase RLIM

RNF12

Q9NVW2

RLIM; RNF12

E. coli

A DNA sequence encoding the human RLIM (NP_899196.1) 276-350 aa was fused with the polyhistidine tag

Human

Not tested.