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Product Name
Human RENALASE Recombinant protein (His tag)
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Description
Catalyzes the oxidation of the less abundant 1,2-dihydro-beta-NAD(P) and 1,6-dihydro-beta-NAD(P) to form beta-NAD(P)(+). The enzyme hormone is secreted by the kidney, and circulates in blood and modulates cardiac function and systemic blood pressure. Lowers blood pressure in vivo by decreasing cardiac contractility and heart rate and preventing a compensatory increase in peripheral vascular tone, suggesting a causal link to the increased plasma catecholamine and heightened cardiovascular risk. High concentrations of catecholamines activate plasma renalase and promotes its secretion and synthesis. {PubMed:15841207, PubMed:17385068, PubMed:25531177}.
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Protein name
Renalase
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Protein short names
C10orf59
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Uniprot ID
Q5VYX0
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Gene Name
RNLS; C10orf59
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
A DNA sequence encoding the human RNLS (NP_001026879.2) 1-342 aa was fused with the polyhistidine tag
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Protein Species
Human
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Activity
Not tested.
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Validations
Recombinant human RENALASE SDS-PAGE
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