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Product Name
Human RAN Recombinant protein (GST tag)
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Description
GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle (By similarity). The complex with BIRC5/ survivin plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. Acts as a negative regulator of the kinase activity of VRK1 and VRK2. {, PubMed:10400640, PubMed:18591255, PubMed:18617507, PubMed:8692944}.; Enhances AR-mediated transactivation. Transactivation decreases as the poly-Gln length within AR increases.
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Protein name
GTP-binding nuclear protein Ran
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Protein short names
ARA24
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Uniprot ID
P62826
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Gene Name
RAN; ARA24; OK/SW-cl.81
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
A DNA sequence encoding the human RAN (NP_006316.1) 1-216 aa was fused with the N-terminal GST tag
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Protein Species
Human
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Activity
Not tested.
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Validations
Recombinant human RAN SDS-PAGE
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