Human RAB35 Recombinant protein (GST tag)

Human RAB35 Recombinant protein (GST tag)

• DataSheet
• Material Safety Data Sheets (MSDS)

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in the process of endocytosis and is an essential rate-limiting regulator of the fast recycling pathway back to the plasma membrane. During cytokinesis, required for the postfurrowing terminal steps, namely for intercellular bridge stability and abscission, possibly by controlling phosphatidylinositol 4,5-bis phosphate (PIP2) and SEPT2 localization at the intercellular bridge. May indirectly regulate neurite outgrowth. {PubMed:16950109, PubMed:21951725}.

Ras-related protein Rab-35

RAB1C; RAY

Q15286

RAB35; RAB1C; RAY

E. coli

A DNA sequence encoding the human RAB35 (NP_006852.1) 1-201 aa was fused with the N-terminal GST tag

Human

Not tested.