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Product Name
Human PQBP1 Recombinant protein (His tag)
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Description
Probably functions as scaffold protein that is part of numerous complexes and thereby plays a role in pre-mRNA splicing, transcription regulation and neuron development. Required for normal alternative splicing of target pre-mRNA species (PubMed:23512658). May suppress the ability of POU3F2 to transactivate the DRD1 gene in a POU3F2 dependent manner. Can activate transcription directly or via association with the transcription machinery. May be involved in ATXN1 mutant-induced cell death. The interaction with ATXN1 mutant reduces levels of phosphorylated RNA polymerase II large subunit. {PubMed:10198427, PubMed:10332029, PubMed:12062018, PubMed:20410308, PubMed:23512658}.
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Protein name
Polyglutamine-binding protein 1
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Protein short names
NPW38
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Uniprot ID
O60828
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Gene Name
PQBP1; NPW38; JM26
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
A DNA sequence encoding the human PQBP1 (NP_001027556.1) 1-265 aa was fused with the polyhistidine tag
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Protein Species
Human
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Activity
Not tested.
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Validations
Recombinant human PQBP1(Full length) SDS-PAGE
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