Human PQBP1 Recombinant protein (GST tag)

Human PQBP1 Recombinant protein (GST tag)

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Probably functions as scaffold protein that is part of numerous complexes and thereby plays a role in pre-mRNA splicing, transcription regulation and neuron development. Required for normal alternative splicing of target pre-mRNA species (PubMed:23512658). May suppress the ability of POU3F2 to transactivate the DRD1 gene in a POU3F2 dependent manner. Can activate transcription directly or via association with the transcription machinery. May be involved in ATXN1 mutant-induced cell death. The interaction with ATXN1 mutant reduces levels of phosphorylated RNA polymerase II large subunit. {PubMed:10198427, PubMed:10332029, PubMed:12062018, PubMed:20410308, PubMed:23512658}.

Polyglutamine-binding protein 1

NPW38

O60828

PQBP1; NPW38; JM26

E. coli

A DNA sequence encoding the human PQBP1 (NP_001027556.1) 1-265 aa was fused with the N-terminal GST tag

Human

Not tested.