Human PQBP1 Recombinant protein (GST tag)

Cat.#: 511543

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Product Information

  • Product Name
    Human PQBP1 Recombinant protein (GST tag)
  • Documents
  • Description
    Probably functions as scaffold protein that is part of numerous complexes and thereby plays a role in pre-mRNA splicing, transcription regulation and neuron development. Required for normal alternative splicing of target pre-mRNA species (PubMed:23512658). May suppress the ability of POU3F2 to transactivate the DRD1 gene in a POU3F2 dependent manner. Can activate transcription directly or via association with the transcription machinery. May be involved in ATXN1 mutant-induced cell death. The interaction with ATXN1 mutant reduces levels of phosphorylated RNA polymerase II large subunit. {PubMed:10198427, PubMed:10332029, PubMed:12062018, PubMed:20410308, PubMed:23512658}.
  • Protein name
    Polyglutamine-binding protein 1
  • Protein short names
    NPW38
  • Uniprot ID
    O60828
  • Gene Name
    PQBP1; NPW38; JM26
  • Source/Expression Host
    E. coli
  • Expression Plasmid/cDNA
    A DNA sequence encoding the human PQBP1 (NP_001027556.1) 1-265 aa was fused with the N-terminal GST tag
  • Protein Species
    Human
  • Activity
    Not tested.
  • Validations

    Recombinant human PQBP1 SDS-PAGE

    Recombinant human PQBP1 SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"