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Product Name
Human Perforin Recombinant protein (His tag)
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Description
Plays a key role in secretory granule-dependent cell death, and in defense against virus-infected or neoplastic cells. Plays an important role in killing other cells that are recognized as non-self by the immune system, e.g. in transplant rejection or some forms of autoimmune disease. Can insert into the membrane of target cells in its calcium-bound form, oligomerize and form large pores. Promotes cytolysis and apoptosis of target cells by facilitating the uptake of cytotoxic granzymes. {PubMed:20038786, PubMed:20225066, PubMed:20889983, PubMed:21037563, PubMed:9058810, PubMed:9164947}.
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Protein name
Perforin-1
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Protein short names
PFP
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Uniprot ID
P14222
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Gene Name
PRF1; PFP
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
A DNA sequence encoding the human PRF1 (NP_005032.2) 247-555 aa was fused with the polyhistidine tag
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Protein Species
Human
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Activity
Not tested.
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Validations
Recombinant human Perforin SDS-PAGE
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