-
Product Name
Human PEA15 recombinant protein
- Documents
-
Description
Astrocyticphosphoprotein PEA-15 (PEA15) is a death effector domain (DED)-containing protein. PEA15 is mainly expressed in the central nervous system, principally in astrocytes. Increased PEA15 levels affect tumorigenesis and cancer progression. PEA15 is overexpressed in breast cancers and gliomas as well as in type 2 diabetes. PEA15 blocks Ras-mediated inhibition of integrin activation and modulates the ERK MAP kinase cascade. PEA15 also inhibits RPS6KA3 activities by holding it in the cytoplasm. In addition, PEA15 inhibits both TNFRSF6 and TNFRSF1A mediated CASP8 activity and apoptosis. At present, PEA15 expression is also a significant prognostic marker in ovarian cancer.
-
Protein name
phosphoprotein enriched in astrocytes 15(PEA15)
-
Uniprot ID
Q15121
-
Source/Expression Host
E.coli
-
Expression Plasmid/cDNA
A DNA sequence encoding the Human PEA15 Met1-Ala130 is expressed.
-
Protein Species
Human
-
Purity
>95% as determined by SDS-PAGE.
-
Validations
Human PEA15 recombinant protein
Related Products / Services
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"