Human NEDD4 Recombinant protein (His tag)

Human NEDD4 Recombinant protein (His tag)

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E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Specifically ubiquitinates 'Lys-63' in target proteins (PubMed:23644597). Involved in the pathway leading to the degradation of VEGFR-2/KDFR, independently of its ubiquitin-ligase activity. Monoubiquitinates IGF1R at multiple sites, thus leading to receptor internalization and degradation in lysosomes. Ubiquitinates FGFR1, leading to receptor internalization and degradation in lysosomes. Promotes ubiquitination of RAPGEF2. According to PubMed:18562292 the direct link between NEDD4 and PTEN regulation through polyubiquitination described in PubMed:17218260 is questionable. Involved in ubiquitination of ERBB4 intracellular domain E4ICD. Involved in the budding of many viruses. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. Ubiquitinates TNK2 and regulates EGF-induced degradation of EGFR and TNF2. Involved in the ubiquitination of ebola virus VP40 protein and this ubiquitination plays a role in facilitating viral budding. Ubiquitinates BRAT1 and this ubiquitination is enhanced in the presence of NDFIP1 (PubMed:25631046). {PubMed:11598133, PubMed:17218260, PubMed:18305167, PubMed:18562292, PubMed:20086093, PubMed:21399620, PubMed:21765395, PubMed:23644597, PubMed:25631046}.

E3 ubiquitin-protein ligase NEDD4

KIAA0093; NEDD4-1

P46934

NEDD4; KIAA0093; NEDD4-1; PIG53

E. coli

A DNA sequence encoding the human NEDD4 (NP_001271267.1) 970-1319 aa was fused with the polyhistidine tag

Human

Not tested.