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Product Name
Human NBL1/DAND1 (Fc Tag) recombinant protein
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Description
Possible candidate as a tumor suppressor gene of neuroblastoma. May play an important role in preventing cells from entering the final stage (G1/S) of the transformation process.
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Protein name
Neuroblastoma suppressor of tumorigenicity 1
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Protein short names
DAN; DAND1
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Uniprot ID
P41271
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Gene Name
NBL1; DAN; DAND1
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the human DAN precursor (NP_005371.1) (Met 1-Asp 180) was expressed with C-terminal fused Fc region of human IgG1.
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Protein Species
Human
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Molecular weight
The recombinant human DAN/Fc chimera is a disulfide-linked homodimeric protein. The reduced monomer consists of 403 amino acids and has a calculated molecular mass of 44.4 kDa. As a result of glycosylation, rh DAN/Fc monomer migrates as an approximately 55-60 kDa protein in SDS-PAGE under reducing conditions.
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Purity
> 90 % as determined by SDS-PAGE
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Activity
Measured by its ability to inhibit BMP4 induced activity in MC3T3-E1 Mouse osteoblastic cells. The ED50 for this effect is typically 0.2-1.2 μg/ml in the presence of 50 ng/mL of recombinant human BMP4.
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Validations
Human NBL1 / DAND1 / DAN Protein (Fc Tag) SDS-PAGE
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