Human MPHOSPH8 Recombinant protein (His tag)

Human MPHOSPH8 Recombinant protein (His tag)

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Heterochromatin component that specifically recognizes and binds methylated 'Lys-9' of histone H3 (H3K9me) and promotes recruitment of proteins that mediate epigenetic repression (PubMed:20871592, PubMed:26022416). Mediates recruitment of the HUSH complex to H3K9me3 sites: the HUSH complex is recruited to genomic loci rich in H3K9me3 and is probably required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3 (PubMed:26022416). Binds H3K9me and promotes DNA methylation by recruiting DNMT3A to target CpG sites; these can be situated within the coding region of the gene (PubMed:20871592). Mediates down-regulation of CDH1 expression (PubMed:20871592). {PubMed:20871592, PubMed:26022416}.

M-phase phosphoprotein 8

MPP8

Q99549

MPHOSPH8; MPP8

E. coli

A DNA sequence encoding the human MPHOSPH8 (XP_047286351.1) 1-301 aa was fused with the polyhistidine tag

Human

Not tested.