Human MIB1 Recombinant protein (GST tag)

Human MIB1 Recombinant protein (GST tag)

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E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. Probably mediates ubiquitination and subsequent proteasomal degradation of DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF-induced apoptosis (By similarity). Involved in ubiquitination of centriolar satellite CEP131, CEP290 and PCM1 proteins and hence inhibits primary cilium formation in proliferating cells. Mediates 'Lys-63'-linked polyubiquitination of TBK1, which probably participates in kinase activation. {, PubMed:24121310}.

E3 ubiquitin-protein ligase MIB1

DIP1; KIAA1323; ZZANK2

Q86YT6

MIB1; DIP1; KIAA1323; ZZANK2

E. coli

A DNA sequence encoding the human MIB1 (NP_065825.1) 707-1006 aa was fused with the N-terminal GST tag

Human

Not tested.