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Product Name
Anti-Mib1/Mindbomb Rabbit antibody
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Description
Mib1/Mindbomb Rabbit polyclonal antibody
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Tested applications
WB, ICC/IF
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Species reactivity
Human, Mouse
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Alternative names
MIB; DIP1; ZZZ6; DIP-1; LVNC7; ZZANK2 antibody
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Isotype
Rabbit IgG
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Preparation
Antigen: A synthetic peptide of human Mib1
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Clonality
Polyclonal
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Formulation
Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M Nacl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
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Storage instructions
Store at -20°C. Stable for 12 months from date of receipt.
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Applications
WB: 1/1000
ICC/IF: 1/50
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Validations
Western blot detection of Mib1/Mindbomb in K562,Hela cell lysates using Mib1/Mindbomb Rabbit pAb(1:1000 diluted).Predicted band size:110kDa.Observed band size:110kDa.
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Background
Swiss-Prot Acc.Q86YT6.E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. Probably mediates ubiquitination and subsequent proteasomal degradation of DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF-induced apoptosis . Involved in ubiquitination of centriolar satellite CEP131, CEP290 and PCM1 proteins and hence inhibits primary cilium formation in proliferating cells. Mediates 'Lys-63'-linked polyubiquitination of TBK1, which probably participates in kinase activation.
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