Human MBP Recombinant protein (GST tag)

Human MBP Recombinant protein (GST tag)

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The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T-cells and neural cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. Induces T-cell proliferation. {PubMed:8544862}.

Myelin basic protein

P02686

MBP

E. coli

A DNA sequence encoding the human MBP (NP_001020272.1) 134-304 aa was fused with the N-terminal GST tag

Human

Not tested.