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Product Name
Human MAD1L1 Recombinant protein (His tag)
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Description
Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. May recruit MAD2L1 to unattached kinetochores. Has a role in the correct positioning of the septum. Required for anchoring MAD2L1 to the nuclear periphery. Binds to the TERT promoter and represses telomerase expression, possibly by interfering with MYC binding. {PubMed:10049595, PubMed:12837246, PubMed:20133940}.
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Protein name
Mitotic spindle assembly checkpoint protein MAD1
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Protein short names
MAD1; TXBP181
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Uniprot ID
Q9Y6D9
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Gene Name
MAD1L1; MAD1; TXBP181
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
A DNA sequence encoding the human MAD1L1 (NP_001291452.1) 370-718 aa was fused with the polyhistidine tag
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Protein Species
Human
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Activity
Not tested.
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Validations
Recombinant human MAD1L1 SDS-PAGE
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