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Product Name
Human LIG3 Recombinant protein (His tag)
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Description
Isoform 3 functions as heterodimer with DNA-repair protein XRCC1 in the nucleus and can correct defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents. Isoform 1 is targeted to mitochondria, where it functions as DNA ligase in mitochondrial base-excision DNA repair (PubMed:10207110, PubMed:24674627). {PubMed:10207110, PubMed:24674627}.
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Protein name
DNA ligase 3
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Uniprot ID
P49916
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Gene Name
LIG3
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
254-390 aa encoded by NM_013975 was inserted into PET30a vector
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Protein Species
Human
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Activity
Not tested.
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Validations
Recombinant human LIG3 SDS-PAGE
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