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  • Human KDR recombinant protein (C-human IgG1-Fc)

Human KDR recombinant protein (C-human IgG1-Fc)

Cat.#: 514911


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Product Information

  • Product Name
    Human KDR recombinant protein (C-human IgG1-Fc)
  • Documents
  • Description
    VEGFR2, also called as KDR or Flk-1, is identified as the receptor for VEGF and VEGFC and an early marker for endothelial cell progenitors, whose expression is restricted to endothelial cells in vivo. VEGFR2 was shown to be the primary signal transducer for angiogenesis and the development of pathological conditions such as cancer and diabetic retinopathy. It has been shown that VEGFR2 is expressed mainly in the endothelial cells, and the expression is upregulated in the tumor vasculature. Thus the inhibition of VEGFR2 activity and its downstream signaling are important targets for the treatment of diseases involving angiogenesis. VEGFR2 transduces the major signals for angiogenesis via its strong tyrosine kinase activity. However, unlike other representative tyrosine kinase receptors, VEGFR2 does not use the Ras pathway as a major downstream signaling but rather uses the phospholipase C-protein kinase C pathway to signal mitogen-activated protein (MAP)-kinase activation and DNA synthesis. VEGFR2 is a direct and major signal transducer for pathological angiogenesis, including cancer and diabetic retinopathy, in cooperation with many other signaling partners; thus, VEGFR2 and its downstream signaling appear to be critical targets for the suppression of these diseases. VEGF and VEGFR2-mediated survival signaling is critical to endothelial cell survival, maintenance of the vasculature and alveolar structure and regeneration of lung tissue. Reduced VEGF and VEGFR2 expression in emphysematous lungs has been linked to increased endothelial cell death and vascular regression.Immune Checkpoint Immunotherapy Cancer Immunotherapy Targeted Therapy
  • Protein name
    Kinase insert domain receptor
  • Protein short names
  • Uniprot ID
  • Gene Name
    Kinase insert domain receptor; A type III receptor tyrosine kinase, isoform CRA_a
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the human KDR (NP_002244.1) (Asp120-Lys327) was expressed with the Fc region of human IgG1 at the C-terminus.
  • Protein Species
  • Molecular weight
    The recombinant human KDR consists of 449 amino acids and predicts a molecular mass of 50.4 kDa.
  • Purity
    > 95 % as determined by SDS-PAGE.
  • Activity
    Measured by its ability to inhibit VEGF-dependent proliferation of human umbilical vein endothelial cells (HUVEC) in the presence of 10 ng/mL rhVEGF165. The ED50 for this effect is 20-80 ng/mL.
  • Validations

    Human VEGFR2 / Flk-1 / CD309 / KDR Protein (Domain 2&3, His Tag)

    Human VEGFR2 / Flk-1 / CD309 / KDR Protein (Domain 2&3, His Tag)