Human IL-1R8/IL1RAPL1 (Fc Tag) recombinant protein

Human IL-1R8/IL1RAPL1 (Fc Tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

Interleukin-1 receptor accessory protein-like 1 (IL1RAPL1) is a member of interleukin-1 receptor family. The protein structurally comprises three extracellular immunoglobulin domains, which presumably mediate binding of an as yet unidentified ligand, a transmembrane region, and an intracellular domain, which is likely to enable signalling via the NFkB pathway. The means of signalling is almost certain to be identical to that used by the IL1R family and the more distally related Toll protein. L1RAPL1 protein physically interacts via its 150 aa C-terminal domain with neuronal calcium sensor-1 (NCS-1), a protein widely expressed in neurons and the related chromaffin and PC12 cells. IL1RAPL1 is an integral membrane protein responsible for a nonsyndromic form of mental retardation (MR). It is suggested to affect human cognitive ability to some extent, especially the memory and concentration capability.

Interleukin-1 receptor accessory protein-like 1

MRX21; C030039N24; IL1R8; IL1RAPL1; MRX10; OPHN4; TIGIRR-2; MRX34; IL1RAPL; IL-1R8; 6330532G10RIK; RP23-301L16.1

X5DNQ7

IL1RAPL1; OPHN4

Human Cells

A DNA sequence encoding the human IL1R8 (NP_055086.1) extracellular domain (Met 1-Leu 354) was fused with the Fc region of human IgG1 at the C-terminus.

Human

The recombinant human IL1R8/Fc is a disulfide-linked homodimer. The reduced monomer consists of 574 amino acids and has a predicted molecular mass of 65 kDa. As a result of glycosylation, the rh IL1R8/Fc monomer migrates with an apparent molecular mass of 80-85 kDa in SDS-PAGE under reducing conditions.

> 95 % as determined by SDS-PAGE