Human IL-1F6 (aa 6-158) recombinant protein

Human IL-1F6 (aa 6-158) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

Interleukin-1 family member 6 (IL-1F6), also known as interleukin 36, alpha (IL36A), is a pro-inflammatory cytokine which plays an important role in innate and adaptive immunity. IL-1F6 activates MAPK and NF-kB pathways and is produced by many different cells. This cytokine is a family member of interleukin-1 (IL-1) and plays an important role in the pathophysiology of several diseases. It has been reported that IL-1F6 and IL-1F8, in addition to IL-1F9, activate the pathway leading to NF-kappaB in an IL-1Rrp2-dependent manner in Jurkat cells as well as in multiple other human and mouse cell lines. Activation of the pathway leading to NF-kappaB by IL-1F6 and IL-1F8 follows a similar time course to activation by IL-1beta, suggesting that signaling by the novel family members occurs through a direct mechanism. In a mammary epithelial cell line, NCI/ADR-RES, which naturally expresses IL-1Rrp2, all three cytokines signal without further receptor transfection. IL-1Rrp2 antibodies block activation of the pathway leading to NF-kappaB by IL-1F6, IL-1F8, and IL-1F9 in both Jurkat and NCI/ADR-RES cells. Thus IL-1F6, IL-1F8, and IL-1F9 signal through IL-1Rrp2 and IL-1RAcP.

Interleukin-36 alpha

FIL1(EPSILON); RP23-176J12.4; IL1F9; FIL1; FIL1E; IL-1H1; IL1RP2; IL1(EPSILON); MGC151481; MGC129552; IL1F6; IL-1 EPSILON; MGC129553; MGC151479; IL-1F6

Q9UHA7

IL36A; FIL1E; IL1E; IL1F6

E. coli

A DNA sequence encoding the human IL1F6 (Q9UHA7) (Ala6-Phe158) was expressed and purified, with two additional amino acids (Gly & Pro) at the N-terminus.

Human

The recombinant human IL1F6 consists of 155 amino acids and predicts a molecular mass of 17 .2 KDa. It migrates as an approximately 18 KDa band in SDS-PAGE under reducing conditions.

> 95 % as determined by SDS-PAGE