Human IL-1F6 recombinant protein
Interleukin-1 family member 6 (IL-1F6), also known as interleukin 36, alpha (IL36A), is a pro-inflammatory cytokine which plays an important role in innate and adaptive immunity. IL-1F6 activates MAPK and NF-kB pathways and is produced by many different cells. This cytokine is a family member of interleukin-1 (IL-1) and plays an important role in the pathophysiology of several diseases. It has been reported that IL-1F6 and IL-1F8, in addition to IL-1F9, activate the pathway leading to NF-kappaB in an IL-1Rrp2-dependent manner in Jurkat cells as well as in multiple other human and mouse cell lines. Activation of the pathway leading to NF-kappaB by IL-1F6 and IL-1F8 follows a similar time course to activation by IL-1beta, suggesting that signaling by the novel family members occurs through a direct mechanism. In a mammary epithelial cell line, NCI/ADR-RES, which naturally expresses IL-1Rrp2, all three cytokines signal without further receptor transfection. IL-1Rrp2 antibodies block activation of the pathway leading to NF-kappaB by IL-1F6, IL-1F8, and IL-1F9 in both Jurkat and NCI/ADR-RES cells. Thus IL-1F6, IL-1F8, and IL-1F9 signal through IL-1Rrp2 and IL-1RAcP.
Protein short names
IL-1H1; IL1RP2; IL1(EPSILON); MGC151481; MGC129552; FIL1(EPSILON); IL1F9; RP23-176J12.4; FIL1; FIL1E; IL-1F6; IL1F6; MGC129553; IL-1 EPSILON; MGC151479
IL36A; FIL1E; IL1E; IL1F6
A DNA sequence encoding the mature form of human IL1F6 (Q9UHA7) (Met 1-Phe 158) was expressed and purified.
The recombinant human IL1F6 comprises 158 amino acids and has a calculated molecular mass of 17.7 kDa. It migrates as an approximately 16 kDa band in SDS-PAGE under reducing conditions.
> 92 % as determined by SDS-PAGE
Human IL1F6 / IL36A Protein SDS-PAGE
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