Human IFNG recombinant protein (Native)

Human IFNG recombinant protein (Native)

• DataSheet
• Material Safety Data Sheets (MSDS)

IFN gamma, also known as IFNG, is a secreted protein which belongs to the type I I interferon family. IFN gamma is produced predominantly by natural killer and natural killer T cells as part of the innate immune response, and by CD4 and CD8 cytotoxic T lymphocyte effector T cells once antigen-specific immunity develops. IFN gamma has antiviral, immunoregulatory, and anti-tumor properties. IFNG, in addition to having antiviral activity, has important immunoregulatory functions, it is a potent activator of macrophages, and has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. The IFNG monomer consists of a core of six α-helices and an extended unfolded sequence in the C-terminal region. IFN gamma is critical for innate and adaptive immunity against viral and intracellular bacterial infections and for tumor control. Aberrant IFN gamma expression is associated with a number of autoinflammatory and autoimmune diseases. The importance of IFN gamma in the immune system stems in part from its ability to inhibit viral replication directly, and most importantly from its immunostimulatory and immunomodulatory effects. IFNG also promotes NK cell activity.Immune Checkpoint Immunotherapy Cancer Immunotherapy Targeted Therapy

Interferon gamma

IFG,IFI,IFN gamma,Interferon Gamma

P01579

Interferon gamma; IFN-gamma; Immune interferon

CHO Cells

A DNA sequence encoding the human IFNG (NP_000610.2) (Met 1-Gln 166) was expressed and purified.

Human

The secreted recombinant human IFNG consists of 143 amino acids and has a predicted molecular mass of 16.7 kDa.

> (59.9+28.9) % as determined by SDS-PAGE