Human IFNB1/IFN-beta/Interferon beta (Fc Tag) recombinant protein

Human IFNB1/IFN-beta/Interferon beta (Fc Tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

Interferons (IFNs) are natural glycoproteins belonging to the cytokine superfamily, and are produced by the cells of the immune system of most vertebrates in response to challenges by foreign agents such as viruses, parasites and tumor cells. Interferon-beta (IFN beta) is an extra-cellular protein mediator of host defense and homeostasis. IFN beta has well-established direct antiviral, antiproliferative and immunomodulatory properties. Recombinant IFN beta is approved for the treatment of relapsing-remitting multiple sclerosis. The recombinant IFN beta protein has the theoretical potential to either treat or cause autoimmune neuromuscular disorders by altering the complicated and delicate balances within the immune system networks. It is the most widely prescribed disease-modifying therapy for multiple sclerosis (MS). Large-scale clinical trials have established the clinical efficacy of IFN beta in reducing relapses and slowing disease progression in relapsing-remitting MS. IFN beta therapy was shown to be comparably beneficial for opticospinal MS (OSMS) and conventional MS in Japanese. IFN beta is effective in reducing relapses in secondary progressive MS and may have a modest effect in slowing disability progression. In addition to the common antiviral activity, IFN beta also induces increased production of the p53 gene product which promotes apoptosis, and thus has therapeutic effect against certain cancers. The role of IFN-beta in bone metabolism could warrant its systematic evaluation as a potential adjunct to therapeutic regimens of osteolytic diseases. Furthermore, IFN beta might play a beneficial role in the development of a chronic progressive CNS inflammation.

Interferon beta

RP23-19G2.2; IFB; IFNB1; IFN-BETA; IFN BETA; IFF; IFNB

P01574

IFNB1; IFB; IFNB

Human Cells

A DNA sequence encoding the human IFN? (NP_002167.1) (Met 1-Asn 187) was fused with the Fc region of human IgG1 at the C-terminus.

Human

The recombinant human IFN?/Fc is a disulfide-linked homodimeric protein. The reduced monomer consists of 404 amino acids and has a predicted molecular mass of 46.7 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rh IFN?/Fc monomer is approximately 52 kDa due to glycosylation.

> 95 % as determined by SDS-PAGE

Measured in antiviral assays using WISH human amnion cells infected with vesicular stomatitis virus (VSV). The EC₅₀ for this effect is 0.08-0.8 ng/mL.