Human IFIT1 Recombinant protein (His tag)

Human IFIT1 Recombinant protein (His tag)

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Interferon-induced antiviral RNA-binding protein that specifically binds single-stranded RNA bearing a 5'-triphosphate group (PPP-RNA), thereby acting as a sensor of viral single-stranded RNAs and inhibiting expression of viral messenger RNAs. Single-stranded PPP-RNAs, which lack 2'-O-methylation of the 5' cap and bear a 5'-triphosphate group instead, are specific from viruses, providing a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Directly binds PPP-RNA in a non-sequence-specific manner. Viruses evolved several ways to evade this restriction system such as encoding their own 2'-O-methylase for their mRNAs or by stealing host cap containing the 2'-O-methylation (cap snatching mechanism). Exhibits antiviral activity against several viruses including human papilloma and hepatitis C viruses. {PubMed:19008854, PubMed:19416887, PubMed:21976647, PubMed:23334420}.

Interferon-induced protein with tetratricopeptide repeats 1

G10P1; IFI56; IFNAI1; ISG56

P09914

IFIT1; G10P1; IFI56; IFNAI1; ISG56

E. coli

A DNA sequence encoding the human IFIT1 (NP_001539.3) 340-460 aa was fused with the polyhistidine tag

Human

Not tested.