Human HRD1 Recombinant protein (GST tag)

Human HRD1 Recombinant protein (GST tag)

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• Material Safety Data Sheets (MSDS)

Acts as an E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated UBC7 E2 ligase and transfers it to substrates, promoting their degradation. Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Also promotes the degradation of normal but naturally short-lived proteins such as SGK. Protects cells from ER stress-induced apoptosis. Protects neurons from apoptosis induced by polyglutamine-expanded huntingtin (HTT) or unfolded GPR37 by promoting their degradation. Sequesters p53/TP53 in the cytoplasm and promotes its degradation, thereby negatively regulating its biological function in transcription, cell cycle regulation and apoptosis. {PubMed:12459480, PubMed:12646171, PubMed:12975321, PubMed:14593114, PubMed:16289116, PubMed:16847254, PubMed:17059562, PubMed:17141218, PubMed:17170702, PubMed:22607976}.

E3 ubiquitin-protein ligase synoviolin

HRD1; KIAA1810

Q86TM6

SYVN1; HRD1; KIAA1810

E. coli

A DNA sequence encoding the human SYVN1 (XP_054226167.1) 242-617 aa was fused with the N-terminal GST tag

Human

Not tested.