Human HBEGF/DTR/DTS/HEGFL (His tag) recombinant protein

Human HBEGF/DTR/DTS/HEGFL (His tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

Heparin-binding EGF-like growth factor (HB-EGF) is a 12­16 kDa member of the epidermal growth factor (EGF) family. It possesses an EGF­like domain, and a heparin-binding motif. Mature HB­EGF is a soluble peptide that arises from proteolytic processing of the transmembrane form. Human HB­EGF shows 76% and 73% aa sequence identity with rat and mouse HB­EGF, respectively. It is required for normal cardiac valve formation and normal heart function, promotes smooth muscle cell proliferation. It may be involved in macrophage-mediated cellular proliferation; it is mitogenic for fibroblasts, but not endothelial cells. HB­EGF classified as a group 2 ErbB ligand based on its ability to activate both the EGF/ErbB1 and ErbB4 receptors. Activity associated with ErbB4 binding appears to be limited to non­mitogenic actions, while EGFR binding induces both mitogenic and non­mitogenic activity.

heparin binding EGF like growth factor(HBEGF)

DTR; DTS; HEGFL

Q99075

Human Cells

A DNA sequence encoding the Human HBEGF/DTR/DTS/HEGFL Leu20-Leu148 is expressed with a 6His tag at the C-terminus.

Human

>95% as determined by SDS-PAGE.