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Product Name
Anti-HBEGF/DTR Rabbit antibody
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Description
HBEGF/DTR Rabbit polyclonal antibody
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Tested applications
WB, IHC-P
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Species reactivity
Human, Rat
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Isotype
Rabbit IgG
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Preparation
Antigen: A synthetic peptide of human HBEGF
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Clonality
Polyclonal
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Formulation
Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M Nacl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
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Storage instructions
Store at -20°C. Stable for 12 months from date of receipt.
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Applications
WB: 1/2000-1/10000
IHC: 1/20-1/100
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Validations
Western blot detection of HBEGF in K562,C6,3T3,Hela cell lysates using HBEGF Rabbit pAb(1:1000 diluted).Predicted band size:23kDa.Observed band size:23kDa.
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Background
Swiss-Prot Acc.Q99075.Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor.SitesFeature keyPosition(s)Description
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"