Human HAVCR2/TIM3/TIMD3 (Fc & His tag) recombinant protein

Human HAVCR2/TIM3/TIMD3 (Fc & His tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

Hepatitis A virus cellular receptor 2（HAVCR2）is a single-pass type I membrane protein and it contains 1 Ig-like V-type (immunoglobulin-like) domain. The protein belongs to the immunoglobulin superfamily, and TIM family of proteins. The protein regulates macrophage activation. It inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. It may be also involved in T-cell homing and it is receptor for LGALS9. CD4 (MIM 186940)-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells and their associated cytokines are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. The 2 types of cells also cross-regulate the functions of the other. TIM3 is a Th1-specific cell surface protein that regulates macrophage activation and enhances the severity of experimental autoimmune encephalomyelitis in mice.

hepatitis A virus cellular receptor 2(HAVCR2)

TIM3; TIMD3

Q8TDQ0

Human Cells

A DNA sequence encoding the Human HAVCR2/TIM3/TIMD3 Ser22-Arg200 is expressed with a Fc, 6His tag at the C-terminus.

Human

>95% as determined by SDS-PAGE.