Human GLB1/ELNR1 (His tag) recombinant protein

Human GLB1/ELNR1 (His tag) recombinant protein

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β Galactosidase is a lysosomal β Galactosidase that hydrolyzes the terminal β Galactose from Ganglioside and Keratan sulfate. In lysosome, the mature β Galactosidase protein associates with Cathepsin A and Neuraminidase 1 to form the lysosomal multienzyme complex . An alternative splicing at the RNA level of β Galactosidase results a catalytically inactive β Galactosidase that plays an important role in vascular development. Defects of β-galactosidase (GLB1) are the cause of diseases like GM1-gangliosidosis which is a lysosomal storage disease and Morquio Syndrome B that cause patients to have abnormal elastic fibers. More than 100 mutations have been identified for β Galactosidase, which result in different residual activities of the mutant enzymes and a spectrum of symptoms in the two related diseases.

galactosidase beta 1(GLB1)

ELNR1

P16278

Human Cells

A DNA sequence encoding the Human GLB1/ELNR1 Leu24-Val677 is expressed with a 6His tag at the C-terminus.

Human

>95% as determined by SDS-PAGE.