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Human FGFR2/CD332 (His Tag) recombinant protein

Cat.#: 503280

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Product Information

  • Product Name
    Human FGFR2/CD332 (His Tag) recombinant protein
  • Documents
  • Description
    FGFR2, also known as CD332, belongs to the fibroblast growth factor receptor subfamily where amino acid sequence is highly conserved between members and throughout evolution. FGFR2 acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. It is required for normal embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis and skin development. FGFR2 plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. It also promotes cell proliferation in keratinocytes and imature osteoblasts, but promotes apoptosis in differentiated osteoblasts. FGFR2 signaling is down-regulated by ubiquitination, internalization and degradation. Mutations that lead to constitutive kinase activation or impair normal CD332 maturation, internalization and degradation lead to aberrant signaling. Over-expressed FGFR2 promotes activation of STAT1. Defects in CD3322 are the cause of Crouzon syndrome, Jackson-Weiss syndrome, Apert syndrome, Pfeiffer syndrome, Beare-Stevenson cutis gyrata syndrome, familial scaphocephaly syndrome, lacrimo-auriculo-dento-digital syndrome and Antley-Bixler syndrome without genital anomalies or disordered steroidogenesis.
  • Protein name
    Fibroblast growth factor receptor 2
  • Protein short names
    MGC102519; CD332; AW556123; SVS; CEK3; FGFR7; FGFR2; FGFR-2; AU043015; TK14; TK25; JWS; FGFR-7; CFD1; KGFR; BBDS; KGFRTR; BFR-1; BEK; ECT1; FLJ98662; K-SAM
  • Uniprot ID
    P21802
  • Gene Name
    FGFR2; BEK; KGFR; KSAM
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the human FGFR2-alpha(IIIb) (NP_075259.4) (Met1-Glu378) was expressed with a polyhistidine tag at the C-terminus.
  • Protein Species
    Human
  • Molecular weight
    The recombinant human FGFR2-alpha(IIIb) consists 368 amino acids and predicts a molecular mass of 41.1 kDa.
  • Purity
    > 95 % as determined by SDS-PAGE.
  • Validations

    Human FGFR2 / CD332 Protein (His Tag)

    Human FGFR2 / CD332 Protein (His Tag)

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"