Human FGF1/FGFA recombinant protein

Human FGF1/FGFA recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

FGF acidic, also known as ECGF, FGF-1and HBGF-1, is a non-glycosylated heparin binding growth factor that is expressed in the brain, kidney, retina, smooth muscle cells, bone matrix, osteoblasts, astrocytes and endothelial cells. It is a mitogenic peptide that is produced by multiple cell types and stimulates the proliferation of cells of mesodermal, ectodermal, and endodermal origin. Its association with heparan sulfate is a prerequisite for activation of FGF receptors. Internalized FGF acidic migrates to the nucleus where it is phosphorylated by nuclear PKC delta, exported to the cytosol, dephosphorylated, and degraded. Intracellular FGF acidic inhibits p53 activity and proapoptotic signaling.

fibroblast growth factor 1(FGF1)

FGFA

P05230

E. coli

A DNA sequence encoding the Human FGF1/FGFA Phe16-Asp155 is expressed.

Human

>95% as determined by SDS-PAGE.