Human FCGR1 recombinant protein (C-His)

Human FCGR1 recombinant protein (C-His)

• DataSheet
• Material Safety Data Sheets (MSDS)

High affinity immunoglobulin gamma Fc receptor I, also known as FCGR1 and CD64, is an integral membrane glycoprotein and a member of the immunoglobulin superfamily. CD64 is a high affinity receptor for the Fc region of IgG gamma and functions in both innate and adaptive immune responses. Receptors that recognize the Fc portion of IgG function in the regulation of immune response and are divided into three classes designated CD64, CD32, and CD16. CD64 is structurally composed of a signal peptide that allows its transport to the surface of a cell, three extracellular immunoglobulin domains of the C2-type that it uses to bind antibody, a hydrophobic transmembrane domain, and a short cytoplasmic tail. CD64 is constitutively found on only macrophages and monocytes, but treatment of polymorphonuclear leukocytes with cytokines like IFNγ and G-CSF can induce CD64 expression on these cells. The inactivation of the mouse CD64 resulted in a wide range of defects in antibody Fc-dependent functions. Mouse CD64 is an early participant in Fc-dependent cell activation and in the development of immune responses.

High affinity immunoglobulin gamma Fc receptor I

CD64,Fc gamma RI

P12314

High affinity immunoglobulin gamma Fc receptor I; IgG Fc receptor I; Fc-gamma RI; FcRI; Fc-gamma RIA; FcgammaRIa; CD antigen CD64

CHO Cells

A DNA sequence encoding the human FCGR1A (NP_000557.1) (Met1-Pro288) was expressed with a polyhistidine tag at the C-terminus.

Human

The recombinant human FCGR1A consists of 284 amino acids and predicts a molecular mass of 32.1 kDa.

> 95 % as determined by SDS-PAGE.

Measured by its binding ability in a functional ELISA.Immobilized Human CD64 Protein (Cat：514919) at 10 μg/mL can bind human IgG1,The EC₅₀ of human IgG1 is 6-14 ng/mL.