Human EIF3M Recombinant protein (His tag)

Human EIF3M Recombinant protein (His tag)

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Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. May favor virus entry in case of infection with herpes simplex virus 1 (HSV1) or herpes simplex virus 2 (HSV2). {HAMAP-Rule:MF_03012, PubMed:15919898, PubMed:17403899}.

Eukaryotic translation initiation factor 3 subunit M

HFLB5; PCID1

Q7L2H7

EIF3M; HFLB5; PCID1; GA17; PNAS-125

E. coli

A DNA sequence encoding the human EIF3M (NP_006351.2) 1-374 aa was fused with the polyhistidine tag

Human

Not tested.