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Product Name
Human E2F1 Recombinant protein (GST tag)
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Description
Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F1 binds preferentially RB1 in a cell-cycle dependent manner. It can mediate both cell proliferation and TP53/p53-dependent apoptosis. Blocks adipocyte differentiation by binding to specific promoters repressing CEBPA binding to its target gene promoters (PubMed:20176812). {UniProtKB:Q61501, PubMed:10675335, PubMed:12717439, PubMed:17704056, PubMed:20176812, PubMed:8170954}.
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Protein name
Transcription factor E2F1
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Protein short names
RBBP3
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Uniprot ID
Q01094
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Gene Name
E2F1; RBBP3
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
A DNA sequence encoding the human E2F1 (NP_005216.1) 88-437 aa was fused with the N-terminal GST tag
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Protein Species
Human
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Activity
Not tested.
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Validations
Recombinant human E2F1 SDS-PAGE
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