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Product Name
Human DNMT1 Recombinant protein (His tag)
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Description
Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2. In association with DNMT3B and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. {PubMed:16357870, PubMed:18413740, PubMed:18754681}.
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Protein name
DNA
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Protein short names
AIM; CXXC9; DNMT
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Uniprot ID
A0A7I2V5D0
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Gene Name
DNMT1; AIM; CXXC9; DNMT
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
A DNA sequence encoding the human DNMT1 (NP_001124295.1) 1288-1632 aa was fused with the polyhistidine tag
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Protein Species
Human
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Activity
Not tested.
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Validations
Recombinant human DNMT1 SDS-PAGE
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